Then drill a bit deeper to see what aspects of our metabolism might give an indication of how we may be able to measure our organ reserve and, to finish up ill suggest, some action points for increasing our organ reserve Music. Firstly, organ reserve refers to the ability of an organ to successfully return to its original physiological state, following repeated episodes of stress or injury, or put more simply, the functional capacity of the organs to support life. Now. The word organ in this context refers collectively to our heart, liver, lungs, kidneys and total, skeletal muscle, mass, but really in terms of metabolically active tissue. It probably encompasses more than just those when were young. Our organs have more than enough capacity for basic function. Their limits get tested, but not seriously taxed by illness, injury and environmental toxicity. Its thought that this excess metabolic capacity could serve as an innate defense system, which might help intermediary metabolism cope with increased metabolic demand, chronic or acute stresses and recover from injury as we age. However, our organ reserve diminishes and gets more severely tested and taxed by these same factors and tends not to bounce back as well as it did before. In recent years, researchers have begun trying to give perspective to organ reserve in a physiological context. By expressing how many metabolic processes display excess capacity over and above what is required for normal daily function or in simpler terms, theyre trying to provide the big picture of organ reserve by giving examples of how many small scale processes already possess, their own reserve or extra Capacity built in so to speak, the rate of organ function or decline has been quantified to occur at a linear rate measuring between 0.
5 percent to 1.4 per year, and all indications are its accelerating by our fifth decade. This reality is succinctly expressed in this quote. From a recent study, these observations indicate that aging is characterized by limited organ reserve, whats more its interesting that organ reserve and lean muscle mass appear to be linked throughout our life. Not only that, but an ongoing effort to maintain and even build muscle mass tends to improve or retain the function of vital organs as a whole. So lets poke our nose into the biochemistry a bit and look at several specific examples of excess capacity which are emerging as candidates for measures of organ reserve. Excess capacity or capability is represented in the cell cytosol by surplus production and activity of four of the enzymes used in glycolysis im listing them here, because they take way too long to say these enzymes are present in quantities believed to be at least five to ten Times more than is required for normal activity. The hexose monophosphate shunt and offshoot of the glycolytic pathway produces excess glucose 6 phosphate dehydrogenase, allowing for greater production of nadph, which is crucial in protecting cellular functions from oxidative damage. Excess capacity of complex 4 of the electron transport chain is understood to be several fold over and above what is required, but declines with age. The observed decline in this complex is touted as a possible measure of reduction in organ reserve and heres, a fun fact. Complex. 4 of the electron transport chain is responsible for consuming more than 95 of the oxygen used in a cell, mitochondrial dna or mtdna is observed to have a large degree of redundancy, and the inordinately large number of mt dna per cell might be another useful measure of Excess capacity surplus empty dna can be viewed as carrying out an important role in reducing the accumulation of empty dna mutations themselves, representing a negative impact on energy metabolism, which typically occurs with age telomeres.
Quite the topic for the last couple of decades have also emerged as a candidate for measuring organ reserve. Adequate telomere length, which reduces with age, is understood to protect genetic material and suppress the triggering of replicative senescence. If we can view telomeres as protective of genome stability. Protective of normal gene expression as delaying replicative cell senescence and aberrant cell apoptosis, then quantifying telomere length could be indicative of an organs ability to recover from injury and tolerate stressful conditions. Also exceeding basic physiological demand is sodium potassium atpase, in the membrane of neural cells, making possible the creation of repetitive action potentials and the release of neurotransmitters excess neural capacity is essential for brain plasticity and cognitive function. Heres. Another fun fact sodium potassium atpase is a huge energy hog, consuming up to two thirds of total cellular energy. Okay, admittedly, ive just touched on some pretty specific metabolic pathways and biological systems, but the point of going through these isnt to complicate the discussion of organ reserve nor make it appear inaccessible to those without a deep understanding of the physiology. Its to give just a glimpse of the variety of standout elements of human biology, displaying excess, functional capacity that diminishes with age, whilst also being measurable theyre in presenting themselves as a possible grouping of quantifiable markers, whereby a collective measure of systemic capacity may be derived and Viewed as indicative of a larger decline or simply an ability of our bodily organs and systems to better maintain basic functions and bounce back effectively from injury and stress, the concept of organ reserve is complex and tricky to convey.
So i hope ive at least gone some way to presenting a big picture of the theory, whilst also providing a little insight into microscopic cellular pathways of real consequence when viewed as a collective, somewhat aligned to the concept of biological aging in a sense. So, to finish up heres a couple of action points we can employ to help preserve or even increase our organ reserve, one cut down on foods that cause oxidative, stress and systemic inflammation that consume the excess capacity of important biological pathways. This means avoiding trans fats, omega 6 fats, too much alcohol grain based foods and particularly sugar and other refined carbohydrates. These nasty foods also disrupt hormone levels that are key to maintaining and building lean muscle, mass and supporting healthy organ function. Foods to focus on are nutrient dense, veggies, oily fish for omega 3s and quality red meat, all of which tend not to cause oxidative stress. Two lots of moderate activity coupled with short spurts of high energy output and nothing beats weight bearing anaerobic activity for building muscle mass, while also building excess capacity in essential physiological pathways, avoid long term chronic cardio exercise because it raises cortisol levels which can deplete muscle and Taxes, the bodys organs and the immune functions that support them there. It is a brief overview of organ reserve. Thank you so much for watching and if you found this information useful, then please consider clicking the like button.